Dermatopathic lymphadenopathya clinicopathologic analysis. Dermatopathic lymphadenitis dl is a reactive lymphoid hyperplasia that. However, the presence of lap and their histological type may have clinical relevance. Dermatopathic lymphadenitis dl is a reactive lymphoid hyperplasia that commonly involves the regional lymph nodes in patients with chronic dermatoses, such as exfoliative dermatitis, toxicshock syndrome, pemphigus, psoriasis, eczema, and, in severe cases, mycosis fungoides. The disease is typically associated with a benign pruritic skin disorder. The histologic development and progression of the disease was correlated with the clinical state of the patient. We compared the paracortical area in 4 cases of dermatopathic lymphadenitis dl with the same area in 11 cases of various other reactive conditions of the lymph node by immuno and enzymehistochemical techniques. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. Synonym of dermatopathic lymphadenitis 2010, stefan e. We present a case of a 43yearold male presented with 3 months history of fatigue, fever, and lymphadenopathy. Dl, also known as lipomelanotic reticulosis or pautrierworinger disease, represents a rare form of benign lymphatic hyperplasia associated with most exfoliative or eczematoid inflammatory erythrodermas, including pemphigus, psoriasis, eczema, neurodermatitis, and atrophia senilis. A case of dermatopathic lymphadenopathy associated with hypereosinophilic syndrome dear editor, a 42yearold man presented with a 4week history of erythematous, maculopapular rash over his whole body fig.
In this report, we describe the case of a 56yearold woman diagnosed with left breast invasive ductal carcinoma in remission, who presented with dermatopathic. It is characterized by lymph node enlargement secondary to a typically pruritic skin disorder. Dermatopathic lymphadenitis also known as lipomelanotic reticulosis, or pautrierworinger disease is a rare type of benign lymphatic hyperplasia associated with a variety of exfoliative or eczematoid type inflammatory erythrodermas. The paracortical area in dermatopathic lymphadenitis and. Mohammad khan, university of peshawar, khyber medical college answered sep. Dermatopathic lymphadenitis is a rare benign lymphatic hyperplasia commonly associated with exfoliative or. Dermatopathic lymphadenopathy is a distinctive type of paracortical hyperplasia in which interdigitating dendritic cells are greatly increased. Dermatopathic lymphadenopathy asano 1987 pathology. Axillary and inguinal lymph nodes are most commonly affected. These changes are usually associated with skin disease. Histopathology and expression of the chemokines cxcl10.
Initial workup satisfactorily met the criteria for diagnosis of aosd. The prevalence of lap in sle was 59% in the oldest series,1 12% in the 1993 eurolupus series2 and in the last two decades its prevalence was not mentioned. Dermatopathic lymphadenitis can be seen after epsteinbarr virus ebv, human herpes virus 6 and 7 hhv6, hhv7 infections, human. The relationship between lymph node hyperplasia and cutaneous disease was first described by pantrier and woringer as lipomelanotic. Of interest, this condition can be confused with lymphatic metastasis in adults. Reaction to drainage of melanin and various skin antigens. Castleman disease, dermatopathic lymphadenitis, lupus erythematosus, rheumatoid arthritis, sarcoidosis additional references ioachim. Dermathopathic lymphadenitis is a welldescribed histopathological entity characterized by expansion of subcortical zone by dendritic histocytoid cells.
Dermatopathic lymphadenitis is a rare entity described in patients with. Dermatopathic lymphadenitis should be included in the differential diagnosis of persistent solid masses involving the lateral margin of the breast and should be confirmed by excisional biopsy. Dermatopathic lymphadenitis characteristically presents as a single or multiple enlarged axillary or inguinal lymph nodes. Ioachims lymph node pathology, 4th edition, 2008, orell. Dermatopathic lymphadenitis of the head and neck, journal.
Dorfman disease, castleman disease, kimura disease, kikuchi. Clinical implication of dermatopathic lymphadenopathy. Dermatopathic lymphadenitis of the head and neck dermatopathic lymphadenitis of the head and neck winter, leslie k spiegel, jeffrey h king, thomas 20070201 00. Interdigitating reticulum cells idcs with broad cytoplasm, innumerable cytoplasmic interdigitation, and bizarre shaped nuclei are the most striking cell type in dpl. Knowles, neoplastic hematopathology, isbn, page 561.
What is the plural of dermatopathic lymphadenopathy. The histologic picture of dermatopathic lymphadenitis may be associated with a variety of. Lymphadenitis is a feature of many bacterial, viral, fungal, and protozoal infections. Ab0547 lymphadenopathy in systemic lupus erythematosus. Pdf on nov 26, 2015, na hu and others published dermatopathic lymphadenitis find, read and cite all the research you need on. In pathology, dermatopathic lymphadenopathy, is lymph node pathology due to skin disease. Sixteen of all the patients were diagnosed with reactive hyperplasia, 4 with hodgkin lymphoma, 3 with nonhodgkin lymphoma, one with langerhans cell histiocytosis, one with dermatopathic lymphadenitis and one patient was diagnosed with kikuchi fujimato disease table ii. If it is proven by biopsy, close observation for development of lymphomas. Forty cases of dermatopathic lymphadenopathy were found in a series of 906 consecutive lymph node biopsies 4. Dermatopathic lymphadenitis article about dermatopathic.
An axillary lymph node from a patient with psoriasis is shown. Follicular lymphoid hyperplasia is present in the early stages of dermatopathic lymphadenopathy, and smears show lhas, a polymorphous lymphocyte population, and variable numbers of figure 7. Dermatopathic lymphadenitis presenting as lateral breast. Dermatopathic lymphadenitis in a patient with pemphigus.
Dermatopathic lymphadenopathy is a distinctive reaction pattern in lymph nodes characterized by paracortical hyperplasia composed of interdigitating dendritic cells idc, langerhans cells lc, macrophages containing melanin pigment, and small tcells. Dermatopathic lymphadenitis represents a benign form of reactive lymph node hyperplasia. Because the association of such lymphadenopathy with skin lesions can arouse the. Diagnostic surgical pathology of the head and neck second edition, 2009. Bardales, lymph node cytopathology, isbn, page 104. Dermatopathic lymphadenitis is a rare entity described in patients with human immunodeficiency virus infection. Dermatopathic lymphadenopathy is a distinctive form of paracortical lymph node hyperplasia that usually occurs in the setting of. Dermatopathic lymphadenitis definition of dermatopathic. The noun dermatopathic lymphadenopathy can be countable or uncountable in more general, commonly used, contexts, the plural form will also be dermatopathic lymphadenopathy however, in more specific contexts, the plural form can also be dermatopathic lymphadenopathies e. In addition, electron microscopy was performed on threee cases of dl.
Lymphadenitis dermatologic disorders merck manuals. Dermatopathic lymphadenitis is usuall associated with a lymphoma or some other like condition. Lawenda on dermatopathic lymphadenopathy treatment. Dermatopathic lymphadenitis also known as lipomelanotic reticulosis, or pautrierworinger disease is a rare type of benign lymphatic hyperplasia associated. What is the treatment of dermatopathic lymphadenitis. These include reactive lymphoid hyperplasia rlh, dermatopathic lymphadenitis dln, rosai.
Background some patients with systemic lupus erythematosus sle have lymphadenopathy lap at diagnosis or at followup. Dermatopathic lymphadenitis is a histopathologic diagnosis of patients with enlarged lymph nodes classically in the setting of a variety of inflammatory erthrodermas without known malignancy. Dermatopathic lymphadenopathy is a welldefined histopathologic entity with an underestimated prevalence in the general population. To clarify the clinicopathologic and immunohistochemical features of dermatopathic lymphadenopathy not associated with mycosis fungoides among japanese, 19 patients were studied. The lymph nodes are usually discrete, superficial, nontender, firm, and freely movable. Fine needle aspiration cytology of dermatopathic lymphadenitis article pdf available in acta cytologica 426. The histological features of dermatopathic lymphadenitis dl include nodular expansion of the palestaining paracortical zones with proliferation of macrophages containing melanin pigment. Prior editions are available for download on our website. Lymphadenopathies in patients with pemphigus vulgaris pv have been attributed to several causes, including infections, malignant melanoma, castlemans disease, or lymphoma.
Dermatopathic lymphadenopathy a clinicopathologic analysis of lymph node biopsy over a fifteenyear period. For claims with a date of service on or after october 1, 2015, use an. In some cases actual disappearance of the adenopathy has been observed. Dermatopathic lymphadenitis mimicking breast cancer with. The code is valid for the year 2020 for the submission of hipaacovered transactions. The pallor is due to histiocyte proliferation in the paracortical regions of the node. Dermatopathic lymphadenopathy with increased igg4positive. Dermatopathic lymphadenitis dl represents a rare benign lymphatic hyperplasia commonly associated with exfoliative or eczematoid dermatitis. Doctors give trusted, helpful answers on causes, diagnosis, symptoms, treatment, and more. Dermatopathic lymphadenopathy definition reactive paracortical hyperplasia of lymph node characterized by an increased number of interdigitating dendritic cells, langerhans cells, and histiocytes with cytoplasmic melanin deposits and lipid vacuoles. Dermatopathic lymphadenopathy is diagnosed by a lymph node biopsy.
Dermatopathic lymphadenopathy dpl is characterized by lymph node enlargement with reactive process and is generally caused by chronic inflammatory skin disease. Dermatopathic lymphadenopathy treatment answers on healthtap. The axillary and inguinal regions are most commonly affected, although occasionally it can present in the head and neck as well. Dermatopathic lymphadenitis dl is a rare type of benign reactive lymphatic hyperdysplasia associated with skin lesions of the exfoliative or eczematoid type, including pemphigus, psoriasis, eczema, atopic dermatitis, and allergic skin diseases. Dermatopathic lymphadenitis in a patient with pemphigus vulgaris. Pdf dermatopathic lymphadenitis dl is a reactive lymphoid hyperplasia that commonly involves the regional lymph nodes in. Here we present a case of dermatopathic lymphadenitis in a 50yearold female who was hiv positive and did not have any obvious skin lesions. Irregularly shaped pale staining areas extending from the capsule into deeper areas of the node are typical of dermatopathic lymphadenopathy.
Orell and sterretts fine needle aspiration cytology, 5th edition, 2011, jaffe. Dermatopathic lymphadenitis is a rare benign lymphatic hyperplasia commonly associated with exfoliative or eczematoid dermatitis. A case of dermatopathic lymphadenopathy associated with. Dermatopathic lymphadenopathy lymphadenitis dermatopathic. Pdf dermatopathic lymphadenitis in a patient with pemphigus. Histological images of the left neck lymph node of the patient with dermatopathic lymphadenitis. Dermatopathic lymphadenitis can occur as a reaction to mycosis fungoides sezary syndrome. Focal lymphadenitis is prominent in streptococcal infection, tb or nontuberculous mycobacterial infection, tularemia, plague, catscratch disease, primary syphilis, lymphogranuloma venereum, chancroid, and genital herpes simplex. Pdf fine needle aspiration cytology of dermatopathic. It has a characteristic pattern of histomorphology and immunohistochemical staining. Fine needle aspiration cytology of dermatopathic lymphadenitis.
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